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SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(Cn3cn[nH]c3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key: InChIKey=TUWCDMHURFSXQL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356227   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM356227
PNG
(2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(2-((5-ox...)
Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(Cn3cn[nH]c3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F
Show InChI InChI=1S/C25H18F4N8O2/c1-36-8-7-19(35-36)15-9-16(18(26)10-17(15)25(27,28)29)23(38)32-20-11-30-21(12-37-13-31-34-24(37)39)33-22(20)14-5-3-2-4-6-14/h2-11,13H,12H2,1H3,(H,32,38)(H,34,39)
PDB
MMDB

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antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.240n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...

US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair