null

SMILES: C[C@@]1(O)C[C@H]2C[C@@H]1C[C@@H]2COc1ncc(cc1Cl)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1

InChI Key: InChIKey=BESVQSQTRRTQCW-WEWYDHJMSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 356959   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM356959 (N-[(5-chloro-6-{[(1R,2S,4R,5R)-5-hydroxy-5-methylb...) Show SMILES C[C@@]1(O)C[C@H]2C[C@@H]1C[C@@H]2COc1ncc(cc1Cl)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1 |t:51| Show InChI InChI=1S/C47H52Cl2N6O6S/c1-46(2)12-10-31(40(24-46)29-4-6-35(48)7-5-29)27-54-14-16-55(17-15-54)36-8-9-39(42(21-36)61-37-20-30-11-13-50-43(30)51-25-37)44(56)53-62(58,59)38-22-41(49)45(52-26-38)60-28-33-19-34-18-32(33)23-47(34,3)57/h4-9,11,13,20-22,25-26,32-34,57H,10,12,14-19,23-24,27-28H2,1-3H3,(H,50,51)(H,53,56)/t32-,33-,34-,47-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition constant (Ki) for binding of representative compounds to Bcl-2 protein, as determined by a TR-FRET (Time-Resolved Fluorescence-Resonan...				Citation and Details BindingDB Entry DOI: 10.7270/Q21V5J59
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM356959 (N-[(5-chloro-6-{[(1R,2S,4R,5R)-5-hydroxy-5-methylb...) Show SMILES C[C@@]1(O)C[C@H]2C[C@@H]1C[C@@H]2COc1ncc(cc1Cl)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1 |t:51| Show InChI InChI=1S/C47H52Cl2N6O6S/c1-46(2)12-10-31(40(24-46)29-4-6-35(48)7-5-29)27-54-14-16-55(17-15-54)36-8-9-39(42(21-36)61-37-20-30-11-13-50-43(30)51-25-37)44(56)53-62(58,59)38-22-41(49)45(52-26-38)60-28-33-19-34-18-32(33)23-47(34,3)57/h4-9,11,13,20-22,25-26,32-34,57H,10,12,14-19,23-24,27-28H2,1-3H3,(H,50,51)(H,53,56)/t32-,33-,34-,47-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.				US Patent US10213433 (2019) BindingDB Entry DOI: 10.7270/Q23F4RZ6
					More data for this Ligand-Target Pair