BDBM356996 5-Amino-N-(4-chloro-2-fluoro-phenyl)-1-(o-tolyl)-1H-pyrazole-4-carboxamide::US10214509, Example 7

SMILES: Cc1ccccc1-n1ncc(C(=O)Nc2ccc(Cl)cc2F)c1N

InChI Key: InChIKey=NOIVKFYZKCOCBF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 356996   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM356996 (5-Amino-N-(4-chloro-2-fluoro-phenyl)-1-(o-tolyl)-1...) Show SMILES Cc1ccccc1-n1ncc(C(=O)Nc2ccc(Cl)cc2F)c1N Show InChI InChI=1S/C17H14ClFN4O/c1-10-4-2-3-5-15(10)23-16(20)12(9-21-23)17(24)22-14-7-6-11(18)8-13(14)19/h2-9H,20H2,1H3,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Almirall, S.A. US Patent					Assay Description Cell LinesStable cell lines expressing the full-length protein of the voltage-gated sodium channels Nav1.7 or Nav1.5, with or without one beta-1, bet...				US Patent US10214509 (2019) BindingDB Entry DOI: 10.7270/Q2FQ9ZWJ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM356996 (5-Amino-N-(4-chloro-2-fluoro-phenyl)-1-(o-tolyl)-1...) Show SMILES Cc1ccccc1-n1ncc(C(=O)Nc2ccc(Cl)cc2F)c1N Show InChI InChI=1S/C17H14ClFN4O/c1-10-4-2-3-5-15(10)23-16(20)12(9-21-23)17(24)22-14-7-6-11(18)8-13(14)19/h2-9H,20H2,1H3,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Almirall, S.A. US Patent					Assay Description Cell LinesStable cell lines expressing the full-length protein of the voltage-gated sodium channels Nav1.7 or Nav1.5, with or without one beta-1, bet...				US Patent US10214509 (2019) BindingDB Entry DOI: 10.7270/Q2FQ9ZWJ
					More data for this Ligand-Target Pair