BDBM357002 5-Amino-3-ethyl-1-(2-methoxyphenyl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazole-4-carboxamide::US10214509, Example 114
SMILES: CCc1nn(c(N)c1C(=O)Nc1ccc(cn1)C(F)(F)F)-c1ccccc1OC
InChI Key: InChIKey=MNPBSJCEWUOKHL-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM357002 (5-Amino-3-ethyl-1-(2-methoxyphenyl)-N-(5-(trifluor...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Almirall, S.A. US Patent | Assay Description Cell LinesStable cell lines expressing the full-length protein of the voltage-gated sodium channels Nav1.7 or Nav1.5, with or without one beta-1, bet... | US Patent US10214509 (2019) BindingDB Entry DOI: 10.7270/Q2FQ9ZWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM357002 (5-Amino-3-ethyl-1-(2-methoxyphenyl)-N-(5-(trifluor...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Almirall, S.A. US Patent | Assay Description Cell LinesStable cell lines expressing the full-length protein of the voltage-gated sodium channels Nav1.7 or Nav1.5, with or without one beta-1, bet... | US Patent US10214509 (2019) BindingDB Entry DOI: 10.7270/Q2FQ9ZWJ | |||||||||||
More data for this Ligand-Target Pair |