BDBM357004 5-Amino-N-(5-chloro-2-pyridyl)-1-(3-fluoro-2-methylphenyl)-3-methyl-pyrazole-4-carboxamide::US10214509, Example 137
SMILES: Cc1nn(c(N)c1C(=O)Nc1ccc(Cl)cn1)-c1cccc(F)c1C
InChI Key: InChIKey=RZGDNQIOOQDAAD-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM357004 (5-Amino-N-(5-chloro-2-pyridyl)-1-(3-fluoro-2-methy...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Almirall, S.A. US Patent | Assay Description Cell LinesStable cell lines expressing the full-length protein of the voltage-gated sodium channels Nav1.7 or Nav1.5, with or without one beta-1, bet... | US Patent US10214509 (2019) BindingDB Entry DOI: 10.7270/Q2FQ9ZWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM357004 (5-Amino-N-(5-chloro-2-pyridyl)-1-(3-fluoro-2-methy...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Almirall, S.A. US Patent | Assay Description Cell LinesStable cell lines expressing the full-length protein of the voltage-gated sodium channels Nav1.7 or Nav1.5, with or without one beta-1, bet... | US Patent US10214509 (2019) BindingDB Entry DOI: 10.7270/Q2FQ9ZWJ | |||||||||||
More data for this Ligand-Target Pair |