BDBM357254 2-(5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazole-4-carbonyl)-1H-indole-6-carbonitrile::US10214515, Example 17
SMILES: Nc1c(cnn1-c1ccc2[nH]c(nc2c1)C1CC1)C(=O)c1cc2ccc(cc2[nH]1)C#N
InChI Key: InChIKey=OVGRJRAGUWXTCO-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM357254 (2-(5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang Hisun Pharmaceutical Co., Ltd. US Patent | Assay Description The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom... | US Patent US10214515 (2019) BindingDB Entry DOI: 10.7270/Q22J6F46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 4 (Homo sapiens (Human)) | BDBM357254 (2-(5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang Hisun Pharmaceutical Co., Ltd. US Patent | Assay Description The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom... | US Patent US10214515 (2019) BindingDB Entry DOI: 10.7270/Q22J6F46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 3 (Homo sapiens (Human)) | BDBM357254 (2-(5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang Hisun Pharmaceutical Co., Ltd. US Patent | Assay Description The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom... | US Patent US10214515 (2019) BindingDB Entry DOI: 10.7270/Q22J6F46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 2 (Homo sapiens (Human)) | BDBM357254 (2-(5-Amino-1-(2-cyclopropyl-1H-benzo[d]imidazol-5-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang Hisun Pharmaceutical Co., Ltd. US Patent | Assay Description The following assay was used to determine the inhibition rate of the preferred compounds of the present invention to the kinase activity of the recom... | US Patent US10214515 (2019) BindingDB Entry DOI: 10.7270/Q22J6F46 | |||||||||||
More data for this Ligand-Target Pair |