BDBM357869 US10214536, Compound 36
SMILES: CC(=O)N1CCC(CC1)c1ccc2oc3nc(N)c(cc3c(=O)c2c1)C(O)=O
InChI Key: InChIKey=JLEKSULAPAVAGH-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human)) | BDBM357869 (US10214536, Compound 36) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Kinase assays are commonly used for determining the ability of a small molecule to inhibit enzyme activity. By measuring the degree of phosphorylatio... | US Patent US10214536 (2019) BindingDB Entry DOI: 10.7270/Q2N87D2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human)) | BDBM357869 (US10214536, Compound 36) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres... | Bioorg Med Chem 26: 5443-5461 (2018) Article DOI: 10.1016/j.bmc.2018.09.020 BindingDB Entry DOI: 10.7270/Q2M04858 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human)) | BDBM357869 (US10214536, Compound 36) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres... | Bioorg Med Chem 26: 5443-5461 (2018) Article DOI: 10.1016/j.bmc.2018.09.020 BindingDB Entry DOI: 10.7270/Q2M04858 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human)) | BDBM357869 (US10214536, Compound 36) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o... | Bioorg Med Chem 26: 5443-5461 (2018) Article DOI: 10.1016/j.bmc.2018.09.020 BindingDB Entry DOI: 10.7270/Q2M04858 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human)) | BDBM357869 (US10214536, Compound 36) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o... | Bioorg Med Chem 26: 5443-5461 (2018) Article DOI: 10.1016/j.bmc.2018.09.020 BindingDB Entry DOI: 10.7270/Q2M04858 | |||||||||||
More data for this Ligand-Target Pair |