BDBM3584 9-[(3-Bromophenyl)amino]-1H-pyrrolo[2,3-f]quinazoline::Anilinopyrimidine deriv. 8b::N-(3-bromophenyl)-3,10,12-triazatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),4,7,10,12-hexaen-13-amine::Pyrroloquinazoline deriv. 22
SMILES: Brc1cccc(Nc2ncnc3ccc4cc[nH]c4c23)c1
InChI Key: InChIKey=DRORNTZBMUKMSZ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3584 (9-[(3-Bromophenyl)amino]-1H-pyrrolo[2,3-f]quinazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.24 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Parke-Davis Pharmaceutical Research | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 42: 5464-74 (1999) Article DOI: 10.1021/jm9903949 BindingDB Entry DOI: 10.7270/Q28K7783 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3584 (9-[(3-Bromophenyl)amino]-1H-pyrrolo[2,3-f]quinazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.24 | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Auckland | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 39: 918-28 (1996) Article DOI: 10.1021/jm950692f BindingDB Entry DOI: 10.7270/Q2222RZB | |||||||||||
More data for this Ligand-Target Pair |