BindingDB PrimarySearch

null

SMILES: CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O

InChI Key: InChIKey=XEYBRNLFEZDVAW-ARSRFYASSA-N

PDB links: 9 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 83 hits for monomerid = 35847
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostacyclin receptor (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at prostanoid IP receptor (unknown origin) by functional assay				J Med Chem 57: 4454-65 (2014) Article DOI: 10.1021/jm401431x BindingDB Entry DOI: 10.7270/Q2CR5VXZ
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells				Bioorg Med Chem 24: 1793-810 (2016) Article DOI: 10.1016/j.bmc.2016.03.006 BindingDB Entry DOI: 10.7270/Q2J67JS7
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	7.5	n/a	n/a	n/a	n/a
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method				ACS Med Chem Lett 7: 306-11 (2016) Article DOI: 10.1021/acsmedchemlett.5b00455 BindingDB Entry DOI: 10.7270/Q2125VKG
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostacyclin receptor (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	347	n/a	n/a	n/a	n/a
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method				ACS Med Chem Lett 7: 306-11 (2016) Article DOI: 10.1021/acsmedchemlett.5b00455 BindingDB Entry DOI: 10.7270/Q2125VKG
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method				ACS Med Chem Lett 7: 306-11 (2016) Article DOI: 10.1021/acsmedchemlett.5b00455 BindingDB Entry DOI: 10.7270/Q2125VKG
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin F2-alpha receptor (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analys...				ACS Med Chem Lett 7: 306-11 (2016) Article DOI: 10.1021/acsmedchemlett.5b00455 BindingDB Entry DOI: 10.7270/Q2125VKG
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis				ACS Med Chem Lett 7: 306-11 (2016) Article DOI: 10.1021/acsmedchemlett.5b00455 BindingDB Entry DOI: 10.7270/Q2125VKG
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP1 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis				ACS Med Chem Lett 7: 306-11 (2016) Article DOI: 10.1021/acsmedchemlett.5b00455 BindingDB Entry DOI: 10.7270/Q2125VKG
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	346	n/a	n/a	n/a	n/a
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...				ACS Med Chem Lett 7: 306-11 (2016) Article DOI: 10.1021/acsmedchemlett.5b00455 BindingDB Entry DOI: 10.7270/Q2125VKG
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP2 subtype (Rattus norvegicus)	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release				Bioorg Med Chem Lett 19: 2075-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.059 BindingDB Entry DOI: 10.7270/Q2PR7W18
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Rattus norvegicus)	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against rat EP4 receptor expressed in HEK293 cells assessed as stimulation of cAMP release				Bioorg Med Chem Lett 19: 2075-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.059 BindingDB Entry DOI: 10.7270/Q2PR7W18
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP2 subtype (Rattus norvegicus)	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat EP2 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 19: 2075-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.059 BindingDB Entry DOI: 10.7270/Q2PR7W18
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Rattus norvegicus)	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 19: 2075-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.059 BindingDB Entry DOI: 10.7270/Q2PR7W18
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Binding affinity to EP4 receptor				J Med Chem 53: 4332-53 (2010) Article DOI: 10.1021/jm9018756 BindingDB Entry DOI: 10.7270/Q21R6QPF
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	0.940	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Binding affinity to EP3 receptor				J Med Chem 53: 4332-53 (2010) Article DOI: 10.1021/jm9018756 BindingDB Entry DOI: 10.7270/Q21R6QPF
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	37.7	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Binding affinity to EP2 receptor				J Med Chem 53: 4332-53 (2010) Article DOI: 10.1021/jm9018756 BindingDB Entry DOI: 10.7270/Q21R6QPF
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP1 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Binding affinity to EP1 receptor				J Med Chem 53: 4332-53 (2010) Article DOI: 10.1021/jm9018756 BindingDB Entry DOI: 10.7270/Q21R6QPF
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Rattus norvegicus)	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Agonist activity at rat EP2 receptor				Bioorg Med Chem 20: 2235-51 (2012) Article DOI: 10.1016/j.bmc.2012.02.018 BindingDB Entry DOI: 10.7270/Q2542P2G
Minase Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Rattus norvegicus)	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3.5	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Agonist activity at rat EP4 receptor				Bioorg Med Chem 20: 2235-51 (2012) Article DOI: 10.1016/j.bmc.2012.02.018 BindingDB Entry DOI: 10.7270/Q2542P2G
Minase Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells				Bioorg Med Chem Lett 13: 1129-32 (2003) BindingDB Entry DOI: 10.7270/Q25T3M1G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
EMD-Serono Research Institute, Inc. Curated by ChEMBL					Assay Description Agonist activity at human EP4 receptor by cAMP assay				Bioorg Med Chem Lett 18: 821-4 (2008) Article DOI: 10.1016/j.bmcl.2007.11.020 BindingDB Entry DOI: 10.7270/Q2W096SW
EMD-Serono Research Institute, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity towards EP1 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs				Bioorg Med Chem Lett 13: 1129-32 (2003) BindingDB Entry DOI: 10.7270/Q25T3M1G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method				Bioorg Med Chem 25: 471-482 (2017) Article DOI: 10.1016/j.bmc.2016.11.014 BindingDB Entry DOI: 10.7270/Q2CF9S3S
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method				Bioorg Med Chem 25: 471-482 (2017) Article DOI: 10.1016/j.bmc.2016.11.014 BindingDB Entry DOI: 10.7270/Q2CF9S3S
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bile salt export pump (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...				Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	0.0200	n/a	n/a	n/a	n/a
Cayman Chemical Company, Inc. Curated by ChEMBL					Assay Description Agonist activity at human EP4 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 ...				J Med Chem 62: 4731-4741 (2019) Article DOI: 10.1021/acs.jmedchem.9b00336 BindingDB Entry DOI: 10.7270/Q22R3W32
Cayman Chemical Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	0.583	n/a	n/a	n/a	n/a
Cayman Chemical Company, Inc. Curated by ChEMBL					Assay Description Agonist activity at human EP4 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA				J Med Chem 62: 4731-4741 (2019) Article DOI: 10.1021/acs.jmedchem.9b00336 BindingDB Entry DOI: 10.7270/Q22R3W32
Cayman Chemical Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	331	n/a	n/a	n/a	n/a
Cayman Chemical Company, Inc. Curated by ChEMBL					Assay Description Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA				J Med Chem 62: 4731-4741 (2019) Article DOI: 10.1021/acs.jmedchem.9b00336 BindingDB Entry DOI: 10.7270/Q22R3W32
Cayman Chemical Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	9.30	n/a	n/a	n/a	n/a
Cayman Chemical Company, Inc. Curated by ChEMBL					Assay Description Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 ...				J Med Chem 62: 4731-4741 (2019) Article DOI: 10.1021/acs.jmedchem.9b00336 BindingDB Entry DOI: 10.7270/Q22R3W32
Cayman Chemical Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
UBE Industries, Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting				J Med Chem 61: 6869-6891 (2018) Article DOI: 10.1021/acs.jmedchem.8b00808 BindingDB Entry DOI: 10.7270/Q2125WXC
UBE Industries, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP1 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
UBE Industries, Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]prostaglandin E2 from recombinant human full length EP1 receptor expressed in Chem-1 cell membranes after 60 mins by liquid scint...				J Med Chem 61: 6869-6891 (2018) Article DOI: 10.1021/acs.jmedchem.8b00808 BindingDB Entry DOI: 10.7270/Q2125WXC
UBE Industries, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
UBE Industries, Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]prostaglandin E2 from recombinant human full length EP3 receptor expressed in Chem-1 cell membranes after 60 mins by liquid scint...				J Med Chem 61: 6869-6891 (2018) Article DOI: 10.1021/acs.jmedchem.8b00808 BindingDB Entry DOI: 10.7270/Q2125WXC
UBE Industries, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM35847 ((15S)-prostaglandin E2 \| (5Z,11alpha,13E,15S)-11,1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
UBE Industries, Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]prostaglandin E2 from recombinant human full length EP4 receptor expressed in Chem-1 cell membranes after 60 mins by liquid scint...				J Med Chem 61: 6869-6891 (2018) Article DOI: 10.1021/acs.jmedchem.8b00808 BindingDB Entry DOI: 10.7270/Q2125WXC
UBE Industries, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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