null

SMILES: CC(=O)N1CCN(C(=O)C1(C)C)c1cccc(-c2c(F)c(Cl)c3c(N)ncnn23)c1F

InChI Key: InChIKey=RHQDGJXQIKDJSN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM358754 (4-acetyl-1-(3-(4-amino-5-chloro-6- fluoropyrrolo[2...) Show SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cccc(-c2c(F)c(Cl)c3c(N)ncnn23)c1F |(6.04,-5.05,;5.64,-3.56,;6.73,-2.47,;4.15,-3.16,;3.06,-4.25,;1.57,-3.85,;1.18,-2.36,;2.27,-1.27,;1.87,.21,;3.75,-1.67,;3.75,-.13,;5.24,-1.27,;-.31,-1.96,;-1.4,-3.05,;-2.89,-2.65,;-3.29,-1.17,;-2.2,-.08,;-2.6,1.41,;-1.69,2.66,;-.15,2.66,;-2.6,3.9,;-1.83,5.24,;-4.06,3.43,;-5.39,4.2,;-5.39,5.74,;-6.73,3.43,;-6.73,1.89,;-5.39,1.12,;-4.06,1.89,;-.71,-.48,;.38,.61,)| Show InChI InChI=1S/C20H19ClF2N6O2/c1-10(30)28-8-7-27(19(31)20(28,2)3)12-6-4-5-11(14(12)22)16-15(23)13(21)17-18(24)25-9-26-29(16)17/h4-6,9H,7-8H2,1-3H3,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...				US Patent US10214537 (2019) BindingDB Entry DOI: 10.7270/Q2HH6NB2
					More data for this Ligand-Target Pair