BDBM35878 5,6-bis(4-chlorophenyl)-N-cyclohexylpyrazine-2-carboxamide::5,6-bis-(4-chloro-phenyl)-pyrazine-2-carboxylicacid cyclohexylamide::5,6-diaryl-pyrazine-2-amide derivative, 6d::CHEMBL227841

SMILES: Clc1ccc(cc1)-c1ncc(nc1-c1ccc(Cl)cc1)C(=O)NC1CCCCC1

InChI Key: InChIKey=FDSVRRAVMKJSOK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35878   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM35878 (5,6-bis(4-chlorophenyl)-N-cyclohexylpyrazine-2-car...) Show SMILES Clc1ccc(cc1)-c1ncc(nc1-c1ccc(Cl)cc1)C(=O)NC1CCCCC1 Show InChI InChI=1S/C23H21Cl2N3O/c24-17-10-6-15(7-11-17)21-22(16-8-12-18(25)13-9-16)28-20(14-26-21)23(29)27-19-4-2-1-3-5-19/h6-14,19H,1-5H2,(H,27,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16.6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D M£lndal Curated by ChEMBL					Assay Description Agonist activity at human CB1 receptor assessed as stimulation of [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 479-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.125 BindingDB Entry DOI: 10.7270/Q2X34XKB
					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM35878 (5,6-bis(4-chlorophenyl)-N-cyclohexylpyrazine-2-car...) Show SMILES Clc1ccc(cc1)-c1ncc(nc1-c1ccc(Cl)cc1)C(=O)NC1CCCCC1 Show InChI InChI=1S/C23H21Cl2N3O/c24-17-10-6-15(7-11-17)21-22(16-8-12-18(25)13-9-16)28-20(14-26-21)23(29)27-19-4-2-1-3-5-19/h6-14,19H,1-5H2,(H,27,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	30
AstraZeneca					Assay Description A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...				Bioorg Med Chem 15: 4077-84 (2007) Article DOI: 10.1016/j.bmc.2007.03.075 BindingDB Entry DOI: 10.7270/Q2028PW8
					More data for this Ligand-Target Pair