BDBM361872 US10221177, Compound 246

SMILES: Cc1cc(Cn2c(=O)n(C)c3ncn(CC(=O)Nc4csc(n4)-c4cnc(C)c(c4)C(F)(F)F)c3c2=O)no1

InChI Key: InChIKey=IFOHXEDFEXQIFK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361872   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM361872 (US10221177, Compound 246) Show SMILES Cc1cc(Cn2c(=O)n(C)c3ncn(CC(=O)Nc4csc(n4)-c4cnc(C)c(c4)C(F)(F)F)c3c2=O)no1 Show InChI InChI=1S/C23H19F3N8O4S/c1-11-4-14(31-38-11)7-34-21(36)18-19(32(3)22(34)37)28-10-33(18)8-17(35)29-16-9-39-20(30-16)13-5-15(23(24,25)26)12(2)27-6-13/h4-6,9-10H,7-8H2,1-3H3,(H,29,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Hydra Biosciences, Inc. US Patent					Assay Description Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...				US Patent US10221177 (2019) BindingDB Entry DOI: 10.7270/Q2445PR8
					More data for this Ligand-Target Pair