BDBM361999 US10221182, Compound E1-1.6::US10221182, Compound E2-1.6

SMILES: FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1

InChI Key:

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 361999   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM361999 (US10221182, Compound E1-1.6 | US10221182, Compound...) Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.2	n/a	n/a	n/a	n/a	n/a	n/a
RUGEN HOLDINGS (CAYMAN) LIMITED US Patent					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				US Patent US10221182 (2019) BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A (Homo sapiens (Human))	BDBM361999 (US10221182, Compound E1-1.6 | US10221182, Compound...) Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
RUGEN HOLDINGS (CAYMAN) LIMITED US Patent					Assay Description TBD				US Patent US10221182 (2019) BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM361999 (US10221182, Compound E1-1.6 | US10221182, Compound...) Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
RUGEN HOLDINGS (CAYMAN) LIMITED US Patent					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				US Patent US10221182 (2019) BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2A (Homo sapiens (Human))	BDBM361999 (US10221182, Compound E1-1.6 | US10221182, Compound...) Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
RUGEN HOLDINGS (CAYMAN) LIMITED US Patent					Assay Description TBD				US Patent US10221182 (2019) BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM361999 (US10221182, Compound E1-1.6 | US10221182, Compound...) Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
RUGEN HOLDINGS (CAYMAN) LIMITED US Patent					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				US Patent US10221182 (2019) BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM361999 (US10221182, Compound E1-1.6 | US10221182, Compound...) Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
RUGEN HOLDINGS (CAYMAN) LIMITED US Patent					Assay Description The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37° C. in a humidified CO2 incubator in the grow...				US Patent US10221182 (2019) BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM361999 (US10221182, Compound E1-1.6 | US10221182, Compound...) Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
RUGEN HOLDINGS (CAYMAN) LIMITED US Patent					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				US Patent US10221182 (2019) BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM361999 (US10221182, Compound E1-1.6 | US10221182, Compound...) Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.2	n/a	n/a	n/a	n/a	n/a	n/a
RUGEN HOLDINGS (CAYMAN) LIMITED US Patent					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				US Patent US10221182 (2019) BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM361999 (US10221182, Compound E1-1.6 | US10221182, Compound...) Show SMILES FC(F)c1ccc(CCN2CCC(Nc3ncnc4[nH]ncc34)C(F)(F)C2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.2	n/a	n/a	n/a	n/a	n/a	n/a
RUGEN HOLDINGS (CAYMAN) LIMITED US Patent					Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...				US Patent US10221182 (2019) BindingDB Entry DOI: 10.7270/Q2VQ34ZZ
					More data for this Ligand-Target Pair