BDBM362172 US10272077, Example 6::US9833448, Example 6

SMILES: Fc1ccccc1[C@@H]1C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N(CC(F)(F)F)C1

InChI Key: InChIKey=MKGOTRHHJCVLEJ-OKTISSRRSA-N

Data: 2 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362172   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM362172 (US10272077, Example 6 | US9833448, Example 6) Show SMILES Fc1ccccc1[C@@H]1C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N(CC(F)(F)F)C1 |r| Show InChI InChI=1S/C28H23F4N5O3/c29-20-6-2-1-4-18(20)17-9-21(25(39)37(13-17)14-28(30,31)32)35-24(38)16-8-15-10-27(11-22(15)34-12-16)19-5-3-7-33-23(19)36-26(27)40/h1-8,12,17,21H,9-11,13-14H2,(H,35,38)(H,33,36,40)/t17-,21+,27+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q25X2C8C
					More data for this Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human))	BDBM362172 (US10272077, Example 6 | US9833448, Example 6) Show SMILES Fc1ccccc1[C@@H]1C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N(CC(F)(F)F)C1 |r| Show InChI InChI=1S/C28H23F4N5O3/c29-20-6-2-1-4-18(20)17-9-21(25(39)37(13-17)14-28(30,31)32)35-24(38)16-8-15-10-27(11-22(15)34-12-16)19-5-3-7-33-23(19)36-26(27)40/h1-8,12,17,21H,9-11,13-14H2,(H,35,38)(H,33,36,40)/t17-,21+,27+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Cells were resuspended in DMEM/F12 (Hyclone) supplemented with 1 g/L BSA and 300 μM isobutyl-methylxanthine. Cells were then plated in a 384-wel...				US Patent US9833448 (2017) BindingDB Entry DOI: 10.7270/Q2BP052K
					More data for this Ligand-Target Pair