BDBM362173 US10272077, Example 11::US9833448, Example 11

SMILES: Fc1cccc(Cl)c1[C@@H]1C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N(CC(F)(F)F)C1

InChI Key: InChIKey=FUGYGCWFKVNINL-VVUMAWNLSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362173   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CGRP type 1 receptor (Homo sapiens (Human))	BDBM362173 (US10272077, Example 11 | US9833448, Example 11) Show SMILES Fc1cccc(Cl)c1[C@@H]1C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N(CC(F)(F)F)C1 |r| Show InChI InChI=1S/C28H22ClF4N5O3/c29-18-4-1-5-19(30)22(18)16-8-20(25(40)38(12-16)13-28(31,32)33)36-24(39)15-7-14-9-27(10-21(14)35-11-15)17-3-2-6-34-23(17)37-26(27)41/h1-7,11,16,20H,8-10,12-13H2,(H,36,39)(H,34,37,41)/t16-,20+,27+/m1/s1	PDB GoogleScholar AffyNet	UniChem	US Patent	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q25X2C8C
					More data for this Ligand-Target Pair
Calcitonin receptor-like receptor (CLR) (Homo sapiens (Human))	BDBM362173 (US10272077, Example 11 | US9833448, Example 11) Show SMILES Fc1cccc(Cl)c1[C@@H]1C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N(CC(F)(F)F)C1 |r| Show InChI InChI=1S/C28H22ClF4N5O3/c29-18-4-1-5-19(30)22(18)16-8-20(25(40)38(12-16)13-28(31,32)33)36-24(39)15-7-14-9-27(10-21(14)35-11-15)17-3-2-6-34-23(17)37-26(27)41/h1-7,11,16,20H,8-10,12-13H2,(H,36,39)(H,34,37,41)/t16-,20+,27+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem	US Patent	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Cells were resuspended in DMEM/F12 (Hyclone) supplemented with 1 g/L BSA and 300 μM isobutyl-methylxanthine. Cells were then plated in a 384-wel...				US Patent US9833448 (2017) BindingDB Entry DOI: 10.7270/Q2BP052K
					More data for this Ligand-Target Pair