BDBM362175 US10272077, Example 26::US9833448, Example 26

SMILES: C[C@@H]1[C@@H](C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N1CC1(CC1)C(F)(F)F)c1ccccc1

InChI Key: InChIKey=GQEUXVCWAIGMFG-DLLPPRPDSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362175   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CGRP type 1 receptor (Homo sapiens (Human))	BDBM362175 (US10272077, Example 26 | US9833448, Example 26) Show SMILES C[C@@H]1[C@@H](C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N1CC1(CC1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C32H30F3N5O3/c1-18-22(19-6-3-2-4-7-19)13-24(28(42)40(18)17-30(9-10-30)32(33,34)35)38-27(41)21-12-20-14-31(15-25(20)37-16-21)23-8-5-11-36-26(23)39-29(31)43/h2-8,11-12,16,18,22,24H,9-10,13-15,17H2,1H3,(H,38,41)(H,36,39,43)/t18-,22-,24+,31+/m1/s1	PDB GoogleScholar AffyNet	UniChem	US Patent	0.0930	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q25X2C8C
					More data for this Ligand-Target Pair
Calcitonin receptor-like receptor (CLR) (Homo sapiens (Human))	BDBM362175 (US10272077, Example 26 | US9833448, Example 26) Show SMILES C[C@@H]1[C@@H](C[C@H](NC(=O)c2cnc3C[C@]4(Cc3c2)C(=O)Nc2ncccc42)C(=O)N1CC1(CC1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C32H30F3N5O3/c1-18-22(19-6-3-2-4-7-19)13-24(28(42)40(18)17-30(9-10-30)32(33,34)35)38-27(41)21-12-20-14-31(15-25(20)37-16-21)23-8-5-11-36-26(23)39-29(31)43/h2-8,11-12,16,18,22,24H,9-10,13-15,17H2,1H3,(H,38,41)(H,36,39,43)/t18-,22-,24+,31+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem	US Patent	0.0930	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Cells were resuspended in DMEM/F12 (Hyclone) supplemented with 1 g/L BSA and 300 μM isobutyl-methylxanthine. Cells were then plated in a 384-wel...				US Patent US9833448 (2017) BindingDB Entry DOI: 10.7270/Q2BP052K
					More data for this Ligand-Target Pair