BDBM362180 US10272077, Example 8 from US 2010/0179166::US9833448, Example 10 from U.S. Pat. No. 7,390,798
SMILES: CC(C)(O)CN1C[C@@H](CC[C@@H](NC(=O)c2ccc3CC4(Cc3c2)C(=O)Nc2ncccc42)C1=O)c1cccc(F)c1F
InChI Key: InChIKey=WAZDMGGJAWEMTD-ZKUVRKPUSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CGRP type 1 receptor (Homo sapiens (Human)) | BDBM362180 (US10272077, Example 8 from US 2010/0179166 | US983...) | PDB GoogleScholar AffyNet | UniChem | US Patent | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline | Assay Description The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ... | J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q25X2C8C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin receptor-like receptor (CLR) (Homo sapiens (Human)) | BDBM362180 (US10272077, Example 8 from US 2010/0179166 | US983...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | UniChem | US Patent | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Cells were resuspended in DMEM/F12 (Hyclone) supplemented with 1 g/L BSA and 300 μM isobutyl-methylxanthine. Cells were then plated in a 384-wel... | US Patent US9833448 (2017) BindingDB Entry DOI: 10.7270/Q2BP052K | |||||||||||
More data for this Ligand-Target Pair |