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SMILES: Cn1cc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12

InChI Key: InChIKey=KZJHQXBCYZKJBO-UWJYYQICSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 362682   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM362682 (US9840498, 8) Show SMILES Cn1cc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12 |r| Show InChI InChI=1S/C27H22FN9O2/c1-35-12-15(11-33-35)22-19(28)7-8-20-23(22)27(39)37(16-5-3-2-4-6-16)26(34-20)21-9-17(38)13-36(21)25-18(10-29)24(30)31-14-32-25/h2-8,11-12,14,17,21,38H,9,13H2,1H3,(H2,30,31,32)/t17-,21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...				US Patent US9840498 (2017) BindingDB Entry DOI: 10.7270/Q25X2C7X
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM362682 (US9840498, 8) Show SMILES Cn1cc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12 |r| Show InChI InChI=1S/C27H22FN9O2/c1-35-12-15(11-33-35)22-19(28)7-8-20-23(22)27(39)37(16-5-3-2-4-6-16)26(34-20)21-9-17(38)13-36(21)25-18(10-29)24(30)31-14-32-25/h2-8,11-12,14,17,21,38H,9,13H2,1H3,(H2,30,31,32)/t17-,21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...				US Patent US9840498 (2017) BindingDB Entry DOI: 10.7270/Q25X2C7X
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM362682 (US9840498, 8) Show SMILES Cn1cc(cn1)-c1c(F)ccc2nc([C@@H]3C[C@H](O)CN3c3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12 |r| Show InChI InChI=1S/C27H22FN9O2/c1-35-12-15(11-33-35)22-19(28)7-8-20-23(22)27(39)37(16-5-3-2-4-6-16)26(34-20)21-9-17(38)13-36(21)25-18(10-29)24(30)31-14-32-25/h2-8,11-12,14,17,21,38H,9,13H2,1H3,(H2,30,31,32)/t17-,21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...				US Patent US9840498 (2017) BindingDB Entry DOI: 10.7270/Q25X2C7X
					More data for this Ligand-Target Pair