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SMILES: Nc1ncnc(N2CCC[C@H]2c2nc3cccc(C#CCO)c3c(=O)n2-c2ccccc2)c1C#N

InChI Key: InChIKey=PAQSIMZGENOPKH-NRFANRHFSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 362706   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM362706 (US9840498, 33) Show SMILES Nc1ncnc(N2CCC[C@H]2c2nc3cccc(C#CCO)c3c(=O)n2-c2ccccc2)c1C#N |r| Show InChI InChI=1S/C26H21N7O2/c27-15-19-23(28)29-16-30-24(19)32-13-5-12-21(32)25-31-20-11-4-7-17(8-6-14-34)22(20)26(35)33(25)18-9-2-1-3-10-18/h1-4,7,9-11,16,21,34H,5,12-14H2,(H2,28,29,30)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...				US Patent US9840498 (2017) BindingDB Entry DOI: 10.7270/Q25X2C7X
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM362706 (US9840498, 33) Show SMILES Nc1ncnc(N2CCC[C@H]2c2nc3cccc(C#CCO)c3c(=O)n2-c2ccccc2)c1C#N |r| Show InChI InChI=1S/C26H21N7O2/c27-15-19-23(28)29-16-30-24(19)32-13-5-12-21(32)25-31-20-11-4-7-17(8-6-14-34)22(20)26(35)33(25)18-9-2-1-3-10-18/h1-4,7,9-11,16,21,34H,5,12-14H2,(H2,28,29,30)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...				US Patent US9840498 (2017) BindingDB Entry DOI: 10.7270/Q25X2C7X
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM362706 (US9840498, 33) Show SMILES Nc1ncnc(N2CCC[C@H]2c2nc3cccc(C#CCO)c3c(=O)n2-c2ccccc2)c1C#N |r| Show InChI InChI=1S/C26H21N7O2/c27-15-19-23(28)29-16-30-24(19)32-13-5-12-21(32)25-31-20-11-4-7-17(8-6-14-34)22(20)26(35)33(25)18-9-2-1-3-10-18/h1-4,7,9-11,16,21,34H,5,12-14H2,(H2,28,29,30)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, USA) (Cat. No. PV5099). The kit contains the fo...				US Patent US9840498 (2017) BindingDB Entry DOI: 10.7270/Q25X2C7X
					More data for this Ligand-Target Pair