Found 12 hits for monomerid = 36350 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
kinesin spindle protein
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
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| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| Assay Description Cell proliferation assay for wild-type cells |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
kinesin spindle protein Mutant (A356T)
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
B.MOAD GoogleScholar AffyNet
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| 66 | n/a | n/a | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
kinesin spindle protein Mutant (A356T)
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
B.MOAD GoogleScholar AffyNet
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| 109 | n/a | n/a | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
kinesin spindle protein
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 2.09E+3 | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| Assay Description Cell proliferation assay for wild-type cells |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
kinesin spindle protein Mutant (D130V)
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
B.MOAD GoogleScholar AffyNet
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| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| Assay Description Cell proliferation assay for ispinesib-resistant DCT116-D130V cell |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Kinesin-like protein 1
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by ChEMBL
| Assay Description Inhibition of C-terminally His6-tagged microtubule-activated KSP motor domain ATPase activity after 15 mins by luciferase-derived luminescence assay |
J Med Chem 54: 4839-46 (2011)
Article DOI: 10.1021/jm200448n BindingDB Entry DOI: 10.7270/Q20V8D5G |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
kinesin spindle protein Mutant (D130V)
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
B.MOAD GoogleScholar AffyNet
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| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| Assay Description Cell proliferation assay for ispinesib-resistant DCT116-D130V cell |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
kinesin spindle protein Mutant (D130V)
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
B.MOAD GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
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| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| Assay Description Cell proliferation assay for ispinesib-resistant DCT116-D130V cell |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
kinesin spindle protein
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 162 | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| Assay Description Cell proliferation assay for wild-type cells |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
kinesin spindle protein
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| Assay Description Cell proliferation assay for wild-type cells |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
kinesin spindle protein
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| Assay Description Cell proliferation assay for wild-type cells |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
kinesin spindle protein Mutant (D130V)
(Homo sapiens (Human)) | BDBM36350
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21) | PDB MMDB
B.MOAD GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 0.830 | n/a | n/a | n/a | n/a | 6.8 | n/a |
GlaxoSmithKline
| Assay Description Cell proliferation assay for ispinesib-resistant DCT116-D130V cell |
Nat Chem Biol 3: 722-6 (2007)
Article DOI: 10.1038/nchembio.2007.34 BindingDB Entry DOI: 10.7270/Q2PK0DHC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |