BDBM36372 (5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-Imidazolidinedione, 11::CID11288934

SMILES: CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O

InChI Key: InChIKey=WIKGAEMMNQTUGL-SNVBAGLBSA-N

Data: 3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 36372   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM36372 ((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...) Show SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O Show InChI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	7.3	30
Tufts University					Assay Description In vitro kinase assay using RIP1				Nat Chem Biol 4: 313-21 (2008) Article DOI: 10.1038/nchembio.83 BindingDB Entry DOI: 10.7270/Q21V5C91
					More data for this Ligand-Target Pair				3D Structure (crystal)
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM36372 ((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...) Show SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O Show InChI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human RIP1 in human U937 cells assessed as inhibition of TNF/zVAD.fmk induced necroptosis after 24 hrs by Cell titer-Glo luminescence a...				J Med Chem 59: 2163-78 (2016) BindingDB Entry DOI: 10.7270/Q26H4K97
					More data for this Ligand-Target Pair				3D Structure (crystal)
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM36372 ((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...) Show SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O Show InChI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human RIP1 (1 to 375 residues) after 4 hrs by ADP-Glo reagent based assay				J Med Chem 59: 2163-78 (2016) BindingDB Entry DOI: 10.7270/Q26H4K97
					More data for this Ligand-Target Pair				3D Structure (crystal)
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM36372 ((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...) Show SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O Show InChI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents	PDB PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of Flag-tagged human RIP1 (1 to 324 residues) after 30 mins by ADP-Glo reagent based assay				J Med Chem 59: 2163-78 (2016) BindingDB Entry DOI: 10.7270/Q26H4K97
					More data for this Ligand-Target Pair				3D Structure (crystal)