BDBM36410 1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, PP162::CID24905148

SMILES: Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1

InChI Key: InChIKey=DTUMIKLOEHJGJT-UHFFFAOYSA-N

Data: 14 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 36410   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PI3K-alpha/ DNA-PK (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ p110-beta (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ p110-delta (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ p110-beta (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
mTOR/ DNA-PK (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ PDGFR (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ Hck (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ Src (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ Src Mutant (T338I) (Homo sapiens (Human)-Gallus gallus (Chicken))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ VEGFR2 (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ EGFR (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ EphB4 (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair
DNA-PK/ Abl (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI InChI=1S/C17H17N7/c18-16-14-15(11-5-7-23-8-6-19-13(23)9-11)22-24(12-3-1-2-4-12)17(14)21-10-20-16/h5-10,12H,1-4H2,(H2,18,20,21)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
					More data for this Ligand-Target Pair