BDBM36411 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, PIK294::CID24905149::PIK294
SMILES: Cc1ccccc1-n1c(Cn2nc(-c3cccc(O)c3)c3c(N)ncnc23)nc2cccc(C)c2c1=O
InChI Key: InChIKey=WFSLJOPRIJSOJR-UHFFFAOYSA-N
Data: 20 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PI3K-alpha/ p110-delta (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of PI3Kdelta (unknown origin) preincubated for 30 mins followed by insulin stimulation for 5 mins by Western blot analysis | J Med Chem 62: 4783-4814 (2019) Article DOI: 10.1021/acs.jmedchem.8b01298 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110δ/p85α (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110-delta/ Abl (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w... | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110-delta/ Hck (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w... | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110-delta/ Src (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w... | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110-delta/ Src Mutant (T338I) (Homo sapiens (Human)-Gallus gallus (Chicken)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w... | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110-delta/ VEGFR2 (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w... | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110-delta/ EGFR (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w... | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110-delta/ EphB4 (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w... | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110-delta/ PDGFR (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w... | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-PK/ p110-delta (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
mTOR/ p110-delta (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Biochemical assay using PI3Ks and diversification of tolyl quinazolinone series. | Chem Biol 17: 123-34 (2010) Article DOI: 10.1016/j.chembiol.2010.01.010 BindingDB Entry DOI: 10.7270/Q2CR5RVT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 486 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Biochemical assay using PI3Ks and diversification of tolyl quinazolinone series. | Chem Biol 17: 123-34 (2010) Article DOI: 10.1016/j.chembiol.2010.01.010 BindingDB Entry DOI: 10.7270/Q2CR5RVT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Biochemical assay using PI3Ks and diversification of tolyl quinazolinone series. | Chem Biol 17: 123-34 (2010) Article DOI: 10.1016/j.chembiol.2010.01.010 BindingDB Entry DOI: 10.7270/Q2CR5RVT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 162 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Biochemical assay using PI3Ks and diversification of tolyl quinazolinone series. | Chem Biol 17: 123-34 (2010) Article DOI: 10.1016/j.chembiol.2010.01.010 BindingDB Entry DOI: 10.7270/Q2CR5RVT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of PI3Kdelta | J Med Chem 55: 8559-81 (2012) Article DOI: 10.1021/jm300847w BindingDB Entry DOI: 10.7270/Q2SN0B47 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110δ/p85α (Homo sapiens (Human)) | BDBM36411 (2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California, San Francisco | Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. | Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9 | |||||||||||
More data for this Ligand-Target Pair |