BDBM3648 3-({4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidin-7-yl}amino)propane-1,2-diol::4-[(3-Bromophenyl)amino]-7-[(2,3-dihydroxypropyl)-amino]pyrido[4,3-d]pyrimidine::pyrido[4,3-d]pyrimidine deriv. 3f
SMILES: OCC(O)CNc1cc2ncnc(Nc3cccc(Br)c3)c2cn1
InChI Key: InChIKey=JLXPNVOGDZTOJF-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3648 (3-({4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Auckland | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 40: 3915-25 (1997) Article DOI: 10.1021/jm970366v BindingDB Entry DOI: 10.7270/Q2NS0S2V | |||||||||||
More data for this Ligand-Target Pair |