BDBM365237 US9868720, No. 96::[2-(3,3-Difluoro-piperidin- 1-yl)-6-pyrrolidin-3- yl-pyrimidin-4-yl]-(4-tri- fluoromethyl-pyridin- 2-yl)-amine

SMILES: FC(F)(F)c1ccnc(Nc2cc(nc(n2)N2CCCC(F)(F)C2)C2CCNC2)c1

InChI Key: InChIKey=CRNKTKRCTBNFBY-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365237   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM365237 (US9868720, No. 96 | [2-(3,3-Difluoro-piperidin- 1-...) Show SMILES FC(F)(F)c1ccnc(Nc2cc(nc(n2)N2CCCC(F)(F)C2)C2CCNC2)c1 Show InChI InChI=1S/C19H21F5N6/c20-18(21)4-1-7-30(11-18)17-27-14(12-2-5-25-10-12)9-16(29-17)28-15-8-13(3-6-26-15)19(22,23)24/h3,6,8-9,12,25H,1-2,4-5,7,10-11H2,(H,26,27,28,29)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
					More data for this Ligand-Target Pair