BDBM365252 1-{4-[2-((R)-2-Methyl- pyrrolidin-1-yl)-6-(4- trifluoromethyl-pyridin-2- ylamino)-pyrimidin-4- yl]-piperidin-1-yl}-ethanone::US9868720, No. 175

SMILES: C[C@@H]1CCCN1c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)C1CCN(CC1)C(C)=O

InChI Key: InChIKey=LKLVAXVFSRKUQS-CQSZACIVSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365252   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM365252 (1-{4-[2-((R)-2-Methyl- pyrrolidin-1-yl)-6-(4- trif...) Show SMILES C[C@@H]1CCCN1c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)C1CCN(CC1)C(C)=O |r| Show InChI InChI=1S/C22H27F3N6O/c1-14-4-3-9-31(14)21-27-18(16-6-10-30(11-7-16)15(2)32)13-20(29-21)28-19-12-17(5-8-26-19)22(23,24)25/h5,8,12-14,16H,3-4,6-7,9-11H2,1-2H3,(H,26,27,28,29)/t14-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
					More data for this Ligand-Target Pair