BDBM365259 US9868720, No. 201::[2-(3,3-Difluoro-pyrrolidin- 1-yl)-6-piperidin-4- yl-pyrimidin-4-yl]-(4- thiophen-2-yl-pyridin-2-yl)- amine

SMILES: FC1(F)CCN(C1)c1nc(Nc2cc(ccn2)-c2cccs2)cc(n1)C1CCNCC1

InChI Key: InChIKey=CIGRSJBXDNLAEO-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365259   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM365259 (US9868720, No. 201 | [2-(3,3-Difluoro-pyrrolidin- ...) Show SMILES FC1(F)CCN(C1)c1nc(Nc2cc(ccn2)-c2cccs2)cc(n1)C1CCNCC1 Show InChI InChI=1S/C22H24F2N6S/c23-22(24)6-10-30(14-22)21-27-17(15-3-7-25-8-4-15)13-20(29-21)28-19-12-16(5-9-26-19)18-2-1-11-31-18/h1-2,5,9,11-13,15,25H,3-4,6-8,10,14H2,(H,26,27,28,29)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
					More data for this Ligand-Target Pair