null
SMILES: CC(C)Oc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12
InChI Key: InChIKey=QOBJISFQPVSAQW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human)) | BDBM366102 (US9873693, Compound 25) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University | Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ... | J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT | |||||||||||
More data for this Ligand-Target Pair |