BDBM366148 US9873693, Compound 71

SMILES: Cc1[nH]c2ncccc2c1-c1cccc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)c1

InChI Key: InChIKey=AMQCFAPOQIAPLN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 366148   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366148 (US9873693, Compound 71) Show SMILES Cc1[nH]c2ncccc2c1-c1cccc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)c1 Show InChI InChI=1S/C28H22F2N4O2/c1-17-25(21-7-3-11-31-26(21)33-17)20-6-2-5-18(13-20)15-32-27(35)22-8-4-12-34(28(22)36)16-19-9-10-23(29)24(30)14-19/h2-14H,15-16H2,1H3,(H,31,33)(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair