BindingDB logo
myBDB logout

null

SMILES: Fc1ccc(Cn2cccc(C(=O)NCc3cc([nH]n3)-c3c[nH]c4ncccc34)c2=O)cc1F

InChI Key: InChIKey=MQNJEIHRMDWVNX-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 366219   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 [51-360]


(Homo sapiens (Human))		BDBM366219
PNG
(US9873693, Compound 142)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cc([nH]n3)-c3c[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C24H18F2N6O2/c25-19-6-5-14(9-20(19)26)13-32-8-2-4-17(24(32)34)23(33)29-11-15-10-21(31-30-15)18-12-28-22-16(18)3-1-7-27-22/h1-10,12H,11,13H2,(H,27,28)(H,29,33)(H,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Duquesne University



Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair