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SMILES: FC(F)(F)c1ccc(Cn2cccc(C(=O)NCc3noc(n3)-c3c[nH]c4ncccc34)c2=O)cc1

InChI Key: InChIKey=IIMBKQPIIFYSNP-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 366220   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 [51-360]


(Homo sapiens (Human))		BDBM366220
PNG
(US9873693, Compound 143)
Show SMILES FC(F)(F)c1ccc(Cn2cccc(C(=O)NCc3noc(n3)-c3c[nH]c4ncccc34)c2=O)cc1
Show InChI InChI=1S/C24H17F3N6O3/c25-24(26,27)15-7-5-14(6-8-15)13-33-10-2-4-17(23(33)35)21(34)30-12-19-31-22(36-32-19)18-11-29-20-16(18)3-1-9-28-20/h1-11H,12-13H2,(H,28,29)(H,30,34)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Duquesne University



Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair