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SMILES: Fc1ccc(Cn2cccc(C(=O)NCc3nccc(n3)-c3c[nH]c4ncccc34)c2=O)cc1F

InChI Key: InChIKey=APPRZYHZOIVDLU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 366223   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 [51-360]


(Homo sapiens (Human))		BDBM366223
PNG
(US9873693, Compound 146)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3nccc(n3)-c3c[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C25H18F2N6O2/c26-19-6-5-15(11-20(19)27)14-33-10-2-4-17(25(33)35)24(34)31-13-22-28-9-7-21(32-22)18-12-30-23-16(18)3-1-8-29-23/h1-12H,13-14H2,(H,29,30)(H,31,34)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Duquesne University



Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair