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SMILES: Fc1ccc(cc1)[C@@H](COc1ccc2[nH]c(=O)[nH]c2c1)NC(=O)c1cccn(Cc2ccc(cc2)C(F)(F)F)c1=O

InChI Key: InChIKey=KFOCVNUBCMMPMA-RUZDIDTESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 366225   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 [51-360]


(Homo sapiens (Human))		BDBM366225
PNG
(US9873693, Compound 148)
Show SMILES Fc1ccc(cc1)[C@@H](COc1ccc2[nH]c(=O)[nH]c2c1)NC(=O)c1cccn(Cc2ccc(cc2)C(F)(F)F)c1=O |r|
Show InChI InChI=1S/C29H20F4N4O4/c30-20-9-5-18(6-10-20)25(16-41-21-11-12-23-24(14-21)36-28(40)35-23)34-26(38)22-2-1-13-37(27(22)39)15-17-3-7-19(8-4-17)29(31,32)33/h1-14,25H,15-16H2,(H,34,38)/t25-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Duquesne University



Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair