null

SMILES: CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CC(N)=O)(CC2)c2ccccc2)cc1

InChI Key: InChIKey=FROBKKOPNQPTKD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366437   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366437 (4-[[8-[4-(2-amino-2- oxo-ethyl)-4-phenyl-1- piperi...) Show SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CC(N)=O)(CC2)c2ccccc2)cc1 Show InChI InChI=1S/C33H40N8O2/c1-38-19-14-27(15-20-38)39(2)31(43)24-10-12-26(13-11-24)35-32-36-30-28(9-6-18-41(30)37-32)40-21-16-33(17-22-40,23-29(34)42)25-7-4-3-5-8-25/h3-13,18,27H,14-17,19-23H2,1-2H3,(H2,34,42)(H,35,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366437 (4-[[8-[4-(2-amino-2- oxo-ethyl)-4-phenyl-1- piperi...) Show SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CC(N)=O)(CC2)c2ccccc2)cc1 Show InChI InChI=1S/C33H40N8O2/c1-38-19-14-27(15-20-38)39(2)31(43)24-10-12-26(13-11-24)35-32-36-30-28(9-6-18-41(30)37-32)40-21-16-33(17-22-40,23-29(34)42)25-7-4-3-5-8-25/h3-13,18,27H,14-17,19-23H2,1-2H3,(H2,34,42)(H,35,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair