new BindingDB logo
myBDB logout

BDBM3665 2-{[3-({4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidin-7-yl}amino)propyl](2-hydroxyethyl)amino}ethan-1-ol::4-[(3-Bromophenyl)amino]-7-[[3-[N,N-bis(2-hydroxyethyl)amino]propyl]amino]pyrido[4,3-d]pyrimidine::pyrido[4,3-d]pyrimidine deriv. 3w

SMILES: OCCN(CCO)CCCNc1cc2ncnc(Nc3cccc(Br)c3)c2cn1

InChI Key: InChIKey=WCVWPEWJCFWBAJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 3665   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3665
PNG
(2-{[3-({4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrim...)
Show SMILES OCCN(CCO)CCCNc1cc2ncnc(Nc3cccc(Br)c3)c2cn1
Show InChI InChI=1S/C20H25BrN6O2/c21-15-3-1-4-16(11-15)26-20-17-13-23-19(12-18(17)24-14-25-20)22-5-2-6-27(7-9-28)8-10-29/h1,3-4,11-14,28-29H,2,5-10H2,(H,22,23)(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.20n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3915-25 (1997)


Article DOI: 10.1021/jm970366v
BindingDB Entry DOI: 10.7270/Q2NS0S2V
More data for this
Ligand-Target Pair