BDBM366678 US9873709, Example 1-275::[4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1- piperidyl]- [1,2,4]triazolo[1,5- a]pyridin-2- yl]amino]phenyl]-(1- methyl-2,3,3a,4,6,6a- hexahydropyrrolo[2,3- c]pyrrol-5- yl)methanone

SMILES: CN1CCC2CN(CC12)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cc1

InChI Key: InChIKey=HSPZVAMSMAVHHX-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366678   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366678 (US9873709, Example 1-275 | [4-[[8-[4-(4- chlorophe...) Show SMILES CN1CCC2CN(CC12)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C32H36ClN7O2/c1-37-16-12-23-19-39(20-28(23)37)30(42)22-4-10-26(11-5-22)34-31-35-29-27(3-2-15-40(29)36-31)38-17-13-32(21-41,14-18-38)24-6-8-25(33)9-7-24/h2-11,15,23,28,41H,12-14,16-21H2,1H3,(H,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366678 (US9873709, Example 1-275 | [4-[[8-[4-(4- chlorophe...) Show SMILES CN1CCC2CN(CC12)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C32H36ClN7O2/c1-37-16-12-23-19-39(20-28(23)37)30(42)22-4-10-26(11-5-22)34-31-35-29-27(3-2-15-40(29)36-31)38-17-13-32(21-41,14-18-38)24-6-8-25(33)9-7-24/h2-11,15,23,28,41H,12-14,16-21H2,1H3,(H,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair