null

SMILES: C[C@H]1CN(CCNC(=O)c2ccc(Nc3nc4c(cccn4n3)N3CCC(CO)(CC3)c3ccc(Cl)cc3)cc2)C[C@@H](C)O1

InChI Key: InChIKey=HMPBTTNGSDGQNT-PSWAGMNNSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366681   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366681 (4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1- p...) Show SMILES C[C@H]1CN(CCNC(=O)c2ccc(Nc3nc4c(cccn4n3)N3CCC(CO)(CC3)c3ccc(Cl)cc3)cc2)C[C@@H](C)O1 |r| Show InChI InChI=1S/C33H40ClN7O3/c1-23-20-39(21-24(2)44-23)19-15-35-31(43)25-5-11-28(12-6-25)36-32-37-30-29(4-3-16-41(30)38-32)40-17-13-33(22-42,14-18-40)26-7-9-27(34)10-8-26/h3-12,16,23-24,42H,13-15,17-22H2,1-2H3,(H,35,43)(H,36,38)/t23-,24+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366681 (4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1- p...) Show SMILES C[C@H]1CN(CCNC(=O)c2ccc(Nc3nc4c(cccn4n3)N3CCC(CO)(CC3)c3ccc(Cl)cc3)cc2)C[C@@H](C)O1 |r| Show InChI InChI=1S/C33H40ClN7O3/c1-23-20-39(21-24(2)44-23)19-15-35-31(43)25-5-11-28(12-6-25)36-32-37-30-29(4-3-16-41(30)38-32)40-17-13-33(22-42,14-18-40)26-7-9-27(34)10-8-26/h3-12,16,23-24,42H,13-15,17-22H2,1-2H3,(H,35,43)(H,36,38)/t23-,24+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair