BDBM366694 2-[4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1- piperidyl]- [1,2,4]triazolo[1,5- a]pyridin-2- yl]amino]pyrazol-1- yl]-1-[4- (methylamino)-1- piperidyl]ethanone::US9873709, Example 1-291

SMILES: CNC1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cn1

InChI Key: InChIKey=YZMKSTLGVGTETL-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366694   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366694 (2-[4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1...) Show SMILES CNC1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cn1 Show InChI InChI=1S/C29H36ClN9O2/c1-31-23-8-13-37(14-9-23)26(41)19-38-18-24(17-32-38)33-28-34-27-25(3-2-12-39(27)35-28)36-15-10-29(20-40,11-16-36)21-4-6-22(30)7-5-21/h2-7,12,17-18,23,31,40H,8-11,13-16,19-20H2,1H3,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366694 (2-[4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1...) Show SMILES CNC1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cn1 Show InChI InChI=1S/C29H36ClN9O2/c1-31-23-8-13-37(14-9-23)26(41)19-38-18-24(17-32-38)33-28-34-27-25(3-2-12-39(27)35-28)36-15-10-29(20-40,11-16-36)21-4-6-22(30)7-5-21/h2-7,12,17-18,23,31,40H,8-11,13-16,19-20H2,1H3,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.360	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair