null

SMILES: CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC#N)cc1

InChI Key: InChIKey=ZTMATJVZOWHTKP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366991   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366991 (4-[[8-[1-(3- cyanopropanoyl)-3,6- dihydro-2H-pyrid...) Show SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC#N)cc1 |t:28| Show InChI InChI=1S/C29H34N8O2/c1-34-17-13-24(14-18-34)35(2)28(39)22-7-9-23(10-8-22)31-29-32-27-25(5-4-16-37(27)33-29)21-11-19-36(20-12-21)26(38)6-3-15-30/h4-5,7-11,16,24H,3,6,12-14,17-20H2,1-2H3,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366991 (4-[[8-[1-(3- cyanopropanoyl)-3,6- dihydro-2H-pyrid...) Show SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC#N)cc1 |t:28| Show InChI InChI=1S/C29H34N8O2/c1-34-17-13-24(14-18-34)35(2)28(39)22-7-9-23(10-8-22)31-29-32-27-25(5-4-16-37(27)33-29)21-11-19-36(20-12-21)26(38)6-3-15-30/h4-5,7-11,16,24H,3,6,12-14,17-20H2,1-2H3,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair