BDBM367 (2R,3R,4R,5R)-2,5-bis[(3,5-difluorophenyl)methoxy]-3,4-dihydroxy-N,N'-bis[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide::1-Valine Methylamide deriv. 20::N1,N6-Bis-[(2R)-hydroxy-1(S)-indanyl]-(2R,3R,4R,5R)-2.5-bis-(3,5-difluorobenzyloxy)-3,4-dihydroxyhexanediamide

SMILES: O[C@H]([C@@H](O)[C@@H](OCc1cc(F)cc(F)c1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12)[C@@H](OCc1cc(F)cc(F)c1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12

InChI Key: InChIKey=JAPYKPCIFHRZGF-JQFCFGFHSA-N

Data: 1 KI

PDB links: 8 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 367   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Protease (Human immunodeficiency virus type 1)	BDBM367 ((2R,3R,4R,5R)-2,5-bis[(3,5-difluorophenyl)methoxy]...) Show SMILES O[C@H]([C@@H](O)[C@@H](OCc1cc(F)cc(F)c1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12)[C@@H](OCc1cc(F)cc(F)c1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |r| Show InChI InChI=1S/C38H36F4N2O8/c39-23-9-19(10-24(40)15-23)17-51-35(37(49)43-31-27-7-3-1-5-21(27)13-29(31)45)33(47)34(48)36(52-18-20-11-25(41)16-26(42)12-20)38(50)44-32-28-8-4-2-6-22(28)14-30(32)46/h1-12,15-16,29-36,45-48H,13-14,17-18H2,(H,43,49)(H,44,50)/t29-,30-,31+,32+,33-,34-,35-,36-/m1/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5	-11.5	n/a	n/a	n/a	n/a	n/a	5.0	30
Linkoping University					Assay Description A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...				J Med Chem 44: 3083-91 (2001) Article DOI: 10.1021/jm001134q BindingDB Entry DOI: 10.7270/Q2DZ06GR
					More data for this Ligand-Target Pair