null

SMILES: FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCN(Cc4cccnc4)CC3)nc12

InChI Key: InChIKey=BSSQEPGQHLMMHM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367095   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM367095 (4,4,4-trifluoro-1-[4-[2- [4-[4-(3- pyridylmethyl) ...) Show SMILES FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCN(Cc4cccnc4)CC3)nc12 |c:11| Show InChI InChI=1S/C32H33F3N8O2/c33-32(34,35)12-9-28(44)41-15-10-24(11-16-41)27-4-2-14-43-29(27)38-31(39-43)37-26-7-5-25(6-8-26)30(45)42-19-17-40(18-20-42)22-23-3-1-13-36-21-23/h1-8,10,13-14,21H,9,11-12,15-20,22H2,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM367095 (4,4,4-trifluoro-1-[4-[2- [4-[4-(3- pyridylmethyl) ...) Show SMILES FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCN(Cc4cccnc4)CC3)nc12 |c:11| Show InChI InChI=1S/C32H33F3N8O2/c33-32(34,35)12-9-28(44)41-15-10-24(11-16-41)27-4-2-14-43-29(27)38-31(39-43)37-26-7-5-25(6-8-26)30(45)42-19-17-40(18-20-42)22-23-3-1-13-36-21-23/h1-8,10,13-14,21H,9,11-12,15-20,22H2,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair