BDBM367246 US10226464, Compound 15

SMILES: COc1ccc2oc3nc(=S)[nH]c(=O)c3cc2c1

InChI Key: InChIKey=XACLKGAPEHFGIP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367246   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear factor NF-kappa-B (NF-kB) (Homo sapiens (Human))	BDBM367246 (US10226464, Compound 15) Show SMILES COc1ccc2oc3nc(=S)[nH]c(=O)c3cc2c1 Show InChI InChI=1S/C12H8N2O3S/c1-16-7-2-3-9-6(4-7)5-8-10(15)13-12(18)14-11(8)17-9/h2-5H,1H3,(H,13,15,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description NFκB/Jurkat/GFP transcriptional reporter cell line was obtained from SBI System Biosciences. NF-κB/Jurkat/GFP™ Reporter cells (5×105 cells)...				Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B (NF-kB) (Homo sapiens (Human))	BDBM367246 (US10226464, Compound 15) Show SMILES COc1ccc2oc3nc(=S)[nH]c(=O)c3cc2c1 Show InChI InChI=1S/C12H8N2O3S/c1-16-7-2-3-9-6(4-7)5-8-10(15)13-12(18)14-11(8)17-9/h2-5H,1H3,(H,13,15,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DNA binding reaction (20 μL) was carried out in 1×DNA Binding Buffer (10 mM Tris, 40 mM NaCl, 1 mM EDTA, 4% glycerol) with 10 nM c-Rel protein a...				Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG
					More data for this Ligand-Target Pair