BDBM367297 US10226464, Compound 64

SMILES: COCCOCCOc1cc2oc3nc(=O)[nH]c(=O)c3cc2cc1Cl

InChI Key: InChIKey=JSZVKGGJABNFRK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367297   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
nf-kb gfp (Homo sapiens (Human))	BDBM367297 (US10226464, Compound 64) Show SMILES COCCOCCOc1cc2oc3nc(=O)[nH]c(=O)c3cc2cc1Cl Show InChI InChI=1S/C16H15ClN2O6/c1-22-2-3-23-4-5-24-13-8-12-9(7-11(13)17)6-10-14(20)18-16(21)19-15(10)25-12/h6-8H,2-5H2,1H3,(H,18,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description NFκB/Jurkat/GFP transcriptional reporter cell line was obtained from SBI System Biosciences. NF-κB/Jurkat/GFP™ Reporter cells (5×105 cells)...				Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG
					More data for this Ligand-Target Pair
emsa (Homo sapiens (Human))	BDBM367297 (US10226464, Compound 64) Show SMILES COCCOCCOc1cc2oc3nc(=O)[nH]c(=O)c3cc2cc1Cl Show InChI InChI=1S/C16H15ClN2O6/c1-22-2-3-23-4-5-24-13-8-12-9(7-11(13)17)6-10-14(20)18-16(21)19-15(10)25-12/h6-8H,2-5H2,1H3,(H,18,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DNA binding reaction (20 μL) was carried out in 1×DNA Binding Buffer (10 mM Tris, 40 mM NaCl, 1 mM EDTA, 4% glycerol) with 10 nM c-Rel protein a...				Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG
					More data for this Ligand-Target Pair