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SMILES: Cc1c(NC(=O)c2cccc(c2)C#N)cnc2n(C)cc(C3CCN(CC3)C(=O)C3CC4CC[C@H]3C4)c12

InChI Key: InChIKey=ZROQDFAPXXPPAV-GJFCNDCISA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368615   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM368615 (US10227346, Example 36 | US10426135, Example 36) Show SMILES Cc1c(NC(=O)c2cccc(c2)C#N)cnc2n(C)cc(C3CCN(CC3)C(=O)C3CC4CC[C@H]3C4)c12 |r| Show InChI InChI=1S/C30H33N5O2/c1-18-26(33-29(36)23-5-3-4-20(13-23)15-31)16-32-28-27(18)25(17-34(28)2)21-8-10-35(11-9-21)30(37)24-14-19-6-7-22(24)12-19/h3-5,13,16-17,19,21-22,24H,6-12,14H2,1-2H3,(H,33,36)/t19?,22-,24?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...				US Patent US10426135 (2019) BindingDB Entry DOI: 10.7270/Q23N25QB
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM368615 (US10227346, Example 36 | US10426135, Example 36) Show SMILES Cc1c(NC(=O)c2cccc(c2)C#N)cnc2n(C)cc(C3CCN(CC3)C(=O)C3CC4CC[C@H]3C4)c12 |r| Show InChI InChI=1S/C30H33N5O2/c1-18-26(33-29(36)23-5-3-4-20(13-23)15-31)16-32-28-27(18)25(17-34(28)2)21-8-10-35(11-9-21)30(37)24-14-19-6-7-22(24)12-19/h3-5,13,16-17,19,21-22,24H,6-12,14H2,1-2H3,(H,33,36)/t19?,22-,24?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Universita di Napoli					Assay Description The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...				J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2SF2ZGV
					More data for this Ligand-Target Pair