BDBM371670 N-(6-fluoropyridin-2-yl)-4-(2-(thiazol-2-yl)-4-(trifluoromethyl)phenyl)chroman-7-sulfonamide::US10239869, Example 96

SMILES: Fc1cccc(NS(=O)(=O)c2ccc3[C@H](CCOc3c2)c2ccc(cc2-c2nccs2)C(F)(F)F)n1

InChI Key: InChIKey=WIJLUUOHOGAOEI-QGZVFWFLSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371670   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371670 (N-(6-fluoropyridin-2-yl)-4-(2-(thiazol-2-yl)-4-(tr...) Show SMILES Fc1cccc(NS(=O)(=O)c2ccc3[C@H](CCOc3c2)c2ccc(cc2-c2nccs2)C(F)(F)F)n1 |r| Show InChI InChI=1S/C24H17F4N3O3S2/c25-21-2-1-3-22(30-21)31-36(32,33)15-5-7-18-17(8-10-34-20(18)13-15)16-6-4-14(24(26,27)28)12-19(16)23-29-9-11-35-23/h1-7,9,11-13,17H,8,10H2,(H,30,31)/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
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