BDBM371672 (R)-4-(2-(6-isopropoxypyridin-3-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)chroman-7-sulfonamide::US10239869, Example 98

SMILES: CC(C)Oc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F

InChI Key: InChIKey=YCLDIBUXJUIEOU-JOCHJYFZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 371672   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM371672 ((R)-4-(2-(6-isopropoxypyridin-3-yl)-4-(trifluorome...) Show SMILES CC(C)Oc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C28H25F3N4O4S/c1-17(2)39-26-9-4-18(16-34-26)24-14-19(28(29,30)31)5-7-21(24)22-10-13-38-25-15-20(6-8-23(22)25)40(36,37)35-27-32-11-3-12-33-27/h3-9,11-12,14-17,22H,10,13H2,1-2H3,(H,32,33,35)/t22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	432	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371672 ((R)-4-(2-(6-isopropoxypyridin-3-yl)-4-(trifluorome...) Show SMILES CC(C)Oc1ccc(cn1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F Show InChI InChI=1S/C28H25F3N4O4S/c1-17(2)39-26-9-4-18(16-34-26)24-14-19(28(29,30)31)5-7-21(24)22-10-13-38-25-15-20(6-8-23(22)25)40(36,37)35-27-32-11-3-12-33-27/h3-9,11-12,14-17,22H,10,13H2,1-2H3,(H,32,33,35)/t22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair