BDBM371788 4-(2-(3,3-difluoropropyl)-4-(trifluoromethyl)phenyl)-N-(pyridazin-3-yl)chroman-7-sulfonamide::US10239869, Example 214

SMILES: FC(F)CCc1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1cccnn1)C(F)(F)F

InChI Key: InChIKey=GNHZBRMVSAIOCC-GOSISDBHSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 371788   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM371788 (4-(2-(3,3-difluoropropyl)-4-(trifluoromethyl)pheny...) Show SMILES FC(F)CCc1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1cccnn1)C(F)(F)F |r| Show InChI InChI=1S/C23H20F5N3O3S/c24-21(25)8-3-14-12-15(23(26,27)28)4-6-17(14)18-9-11-34-20-13-16(5-7-19(18)20)35(32,33)31-22-2-1-10-29-30-22/h1-2,4-7,10,12-13,18,21H,3,8-9,11H2,(H,30,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	635	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM371788 (4-(2-(3,3-difluoropropyl)-4-(trifluoromethyl)pheny...) Show SMILES FC(F)CCc1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1cccnn1)C(F)(F)F |r| Show InChI InChI=1S/C23H20F5N3O3S/c24-21(25)8-3-14-12-15(23(26,27)28)4-6-17(14)18-9-11-34-20-13-16(5-7-19(18)20)35(32,33)31-22-2-1-10-29-30-22/h1-2,4-7,10,12-13,18,21H,3,8-9,11H2,(H,30,31)/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco					Assay Description HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...				J Med Chem 51: 545-52 (2008) BindingDB Entry DOI: 10.7270/Q2NG4SZX
					More data for this Ligand-Target Pair