BDBM371865 2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2,2,2-trifluoroethyl)acetamide::US10239876, Example 22::US10435407, Example 22
SMILES: FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
InChI Key: InChIKey=SYDKMYUOXNXPAU-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM371865 (2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia Institute of Technology | Assay Description This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri... | J Med Chem 51: 2816-32 (2008) BindingDB Entry DOI: 10.7270/Q2D220ZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Discoidin domain-containing receptor 2 (Homo sapiens (Human)) | BDBM371865 (2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) Curated by ChEMBL | Assay Description Inhibition of recombinant GST-tagged human DDR2 by FRET assay | J Med Chem 63: 6578-6599 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human)) | BDBM371865 (2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) Curated by ChEMBL | Assay Description Inhibition of recombinant GST-tagged human DDR1 by FRET assay | J Med Chem 63: 6578-6599 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human)) | BDBM371865 (2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri... | US Patent US10435407 (2019) BindingDB Entry DOI: 10.7270/Q2MP55M4 | |||||||||||
More data for this Ligand-Target Pair |