BDBM372154 N-(3- (morpholino- methyl)phenyl)- 6-(o-tolyl)- 5H-pyrrolo[3,2-d] pyrimidin-2-amine::US10239881, Example A7::US10875863, Example A7
SMILES: Cc1ccccc1-c1cc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2[nH]1
InChI Key: InChIKey=ZAFUBDJXOIHYNU-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase RIPK2 (Homo sapiens (Human)) | BDBM372154 (N-(3- (morpholino- methyl)phenyl)- 6-(o-tolyl)- 5H...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY HEALTH NETWORK US Patent | Assay Description Active RIPK2 was purchased from Life Technologies as His-tagged of catalytic domain (amin acids 1-299) of human RIPK2 kinase expressed in insect cell... | US Patent US10875863 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase RIPK2 (Homo sapiens (Human)) | BDBM372154 (N-(3- (morpholino- methyl)phenyl)- 6-(o-tolyl)- 5H...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
National Taiwan University | Assay Description RIPK2 activity was measured using an indirect ELISA detection system. His—RIPK2 (0.6 nM) was incubated in the presence of 6 μM ATP (Sigma cat # ... | J Med Chem 51: 2795-806 (2008) BindingDB Entry DOI: 10.7270/Q289186K | |||||||||||
More data for this Ligand-Target Pair |