BDBM372156 N-(3-((4- methylpiperazin-1- yl)methyl)phenyl)- 6-(o-tolyl)-5H- pyrrolo[3,2-d] pyrimidin-2-amine::US10239881, Example A9::US10875863, Example A9

SMILES: CN1CCN(Cc2cccc(Nc3ncc4[nH]c(cc4n3)-c3ccccc3C)c2)CC1

InChI Key: InChIKey=SPVDVGUFWOPGCZ-UHFFFAOYSA-N

Data: 2 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372156   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase RIPK2 (Homo sapiens (Human))	BDBM372156 (N-(3-((4- methylpiperazin-1- yl)methyl)phenyl)- 6-...) Show SMILES CN1CCN(Cc2cccc(Nc3ncc4[nH]c(cc4n3)-c3ccccc3C)c2)CC1 Show InChI InChI=1S/C25H28N6/c1-18-6-3-4-9-21(18)22-15-23-24(28-22)16-26-25(29-23)27-20-8-5-7-19(14-20)17-31-12-10-30(2)11-13-31/h3-9,14-16,28H,10-13,17H2,1-2H3,(H,26,27,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY HEALTH NETWORK US Patent					Assay Description Active RIPK2 was purchased from Life Technologies as His-tagged of catalytic domain (amin acids 1-299) of human RIPK2 kinase expressed in insect cell...				US Patent US10875863 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase RIPK2 (Homo sapiens (Human))	BDBM372156 (N-(3-((4- methylpiperazin-1- yl)methyl)phenyl)- 6-...) Show SMILES CN1CCN(Cc2cccc(Nc3ncc4[nH]c(cc4n3)-c3ccccc3C)c2)CC1 Show InChI InChI=1S/C25H28N6/c1-18-6-3-4-9-21(18)22-15-23-24(28-22)16-26-25(29-23)27-20-8-5-7-19(14-20)17-31-12-10-30(2)11-13-31/h3-9,14-16,28H,10-13,17H2,1-2H3,(H,26,27,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University					Assay Description RIPK2 activity was measured using an indirect ELISA detection system. His—RIPK2 (0.6 nM) was incubated in the presence of 6 μM ATP (Sigma cat # ...				J Med Chem 51: 2795-806 (2008) BindingDB Entry DOI: 10.7270/Q289186K
					More data for this Ligand-Target Pair